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Trends in breast and prostate cancer screening and diagnostic procedures during the COVID-19 pandemic in central Massachusetts - Cancer Causes & Control

Purpose We calculated rates of breast and prostate cancer screening and diagnostic procedures performed during the COVID-19 pandemic through December 2021 compared to the same months in 2019 in a ..... see more

Source : https://link.springer.com/article/10.1007/s10552-022-01616-4


Conclusion: The observed decline in two common screening procedures during the COVID-19 pandemic reflects the impact of the pandemic on cancer early detection and signals potential downstream effects on the prognosis of delayed cancer diagnoses. The slower rate of return for breast cancer screening procedures in certain subgroups should be...

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Polyethylene glycol-based gels for treatment of prostate cancer: pictorial review of normal placement and complications - Abdominal Radiology

Rectal spacers are commonly used in the radiotherapy for prostate cancers, serving as a means to protect the rectum and surrounding structures from radiation toxicity. Polyethylene Glycol-Based Gels (SpaceOAR ™ ..... see more

Source : https://link.springer.com/article/10.1007/s00261-022-03630-1


Relevance: Rectal spacers are commonly used in the radiotherapy for prostate cancers, serving as a means to protect the rectum and surrounding structures from radiation toxicity.

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Variations in Medical Necessity Determinations Across Commercial Insurance Carriers for Prostate Cancer Procedures

Variation in commercial insurance coverage may lead to disparity in access to quality cancer care. We evaluated commercial insurance coverage determinations to assess the degree of variation across a national ..... see more

Source : https://www.redjournal.org/article/S0360-3016(22)02597-4/fulltext


Conclusion: Commercial medical policies vary widely in medical necessity determinations for novel prostate cancer treatment procedures that are FDA-approved and covered by Medicare. These data suggest a need for more consistent methodology for medical necessity determination to mitigate the current state where patients have unequal access to...

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Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial - Radiation Oncology

Background Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity. The aim of this study ..... see more

Source : https://ro-journal.biomedcentral.com/articles/10.1186/s13014-022-02103-5


Conclusion/Relevance: Dose-escalation to 82 Gy, facilitated by use of a hydrogel spacer, is safe and feasible, with minimal toxicity up to 37.5 months post-treatment when compared to rates of rectal toxicity in previous dose-escalation trials up to 80 Gy. Trials with longer follow-up of oncological and functional outcomes are required to...

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Metformin and testosterone replacement therapy inversely associated with hormone-associated cancers (prostate, colorectal and male breast cancers) among older White and Black men - PubMed

Pre-diagnostic use of metformin and TTh were, independently and jointly, inversely associated with incident prostate and colorectal cancers. The risk of HRCs was also reduced among White, Black and Other ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35902376/


Conclusion: Pre-diagnostic use of metformin and TTh were, independently and jointly, inversely associated with incident prostate and colorectal cancers. The risk of HRCs was also reduced among White, Black and Other Race men. Greatest reduced associations of prostate and colorectal cancers and HRCs were mainly observed in combination of...

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The rate of prostatic involvement in men treated with radical cystectomy for muscle invasive bladder cancer

Radical cystoprostatectomy (RC) is one standard treatment for muscle-invasive bladder cancer (MIBC) in male patients. Another therapeutic option is trimodal therapy (TMT). Including the prostate in the TMT radiotherapy volume ..... see more

Source : https://www.practicalradonc.org/article/S1879-8500(22)00193-X/fulltext


Conclusion: The high rate of pathological PS involvement seen in cT2 patients and the lack of ability of cT stage to predict PS involvement supports routinely treating the prostate in TMT. Patients with pre-operatively identified bladder neck/trigone tumors, urethral involvement, positive lymph nodes, or prostatic involvement are a subset at...

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Impact of active surveillance for prostate cancer on the risk of depression and anxiety - Scientific Reports

Active surveillance (AS) is a standard treatment option for low risk localized prostate cancer. However, the risk of anxiety and depression compared to other curative strategies, namely radical prostatectomy (RP) ..... see more

Source : https://www.nature.com/articles/s41598-022-17224-w


Conclusion: Patients managed with AS for localized prostate cancer do not report more anxiety or depressive symptoms than patients managed with curative treatment, encouraging the extended use of active surveillance.

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Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial - Radiation Oncology

Background Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity. The aim of this study ..... see more

Source : https://ro-journal.biomedcentral.com/articles/10.1186/s13014-022-02103-5


Conclusions: Dose-escalation to 82 Gy, facilitated by use of a hydrogel spacer, is safe and feasible, with minimal toxicity up to 37.5 months post-treatment when compared to rates of rectal toxicity in previous dose-escalation trials up to 80 Gy. Trials with longer follow-up of oncological and functional outcomes are required to robustly...

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Emerging MR methods for improved diagnosis of prostate cancer by multiparametric MRI - Magnetic Resonance Materials in Physics, Biology and Medicine

Current challenges of using serum prostate-specific antigen (PSA) level-based screening, such as the increased false positive rate, inability to detect clinically significant prostate cancer (PCa) with random biopsy, multifocality in ..... see more

Source : https://link.springer.com/article/10.1007/s10334-022-01031-5


Conclusion/Relevance: These big data can also be utilized in the development of computer-aided diagnostic tools, including automatic segmentation and the detection of clinically significant PCa using machine learning methods.

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The Swedish national guidelines on prostate cancer, part 1: early detection, diagnostics, staging, patient support and primary management of non-metastatic disease

Abstract There is now an unprecedented amount of evidence to consider when revising prostate cancer guidelines. We believe that there is a value in publishing summaries of national clinical guidelines ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/21681805.2022.2094462


Conclusions: The 2022 Swedish prostate cancer guidelines include several new recommendations and some that differ from the European guidelines.

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Remote surgical education using synthetic models combined with an augmented reality headset

Disease and medical device specific simulation phantoms improve surgeons' skills. * Hands-on training using phantoms can be accomplished with both instructor and student at different locations. * A dedicated headset ..... see more

Source : https://www.sciencedirect.com/science/article/pii/S2589845022000410?via=ihub


Conclusion: Remote training using augmented reality eliminates the need for travel. For training programs and workshops, this technology may mitigate the risk of infectious exposures, reduce training cost, and increase proctor availability, allowing training from their own institution or clinic.

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Delphi study to identify consensus on patient selection for hydrogel rectal spacer use during radiation therapy for prostate cancer in the UK

Objectives To identify consensus on patient prioritisation for rectal hydrogel spacer use during radiation therapy for the treatment of prostate cancer in the UK. Design Delphi study consisting of two ..... see more

Source : https://bmjopen.bmj.com/content/12/7/e060506


Conclusion: There is a strong and general agreement that all patients with prostate cancer undergoing radical radiation therapy have the potential to benefit from hydrogel spacers. Currently, not all patients who could potentially benefit can access hydrogel spacers, and access is unequal. Implementation of the consensus recommendations would...

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Prostate Cancer Treatment with Pencil Beam Proton Therapy Using Rectal Spacers sans Endorectal Balloons - PubMed

doi: 10.14338/IJPT-21-00039. 1 Department of Radiation Medicine, Georgetown University Hospital, Washington, DC, USA. 2 Department of Urology, Georgetown University Hospital, Washington, DC, USA. 3 Department of Radiology, Georgetown University Hospital, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35774493/


Conclusion: Early clinical outcomes of patients treated with PBS–PBT using Monte Carlo–based planning, fiducial placement, and rectal spacers sans endorectal balloons demonstrate minimal treatment-related toxicity with good oncologic outcomes. Rectal spacer stabilization without the use of endorectal balloons is feasible for the use of...

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  • July 20, 2022
    Key Points • Source: International Journal of Particle Therapy • Relevance: “Early clinical outcomes of patients treated with PBS–PBT using Monte Carlo–based planning, fiducial placement, and rectal spacers sans endorectal balloons demonstrate minimal treatment-related Show More
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Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies

PURPOSE To study the impact of standard-of-care hormonal therapies on metastatic prostate cancer (mPC) clinical genomic profiles in real-world practice, with a focus on homologous recombination-repair (HRR) genes. PATIENTS AND ..... see more

Source : https://ascopubs.org/doi/10.1200/PO.22.00195


Conclusion: Prevalence of HRR-gene aberrations remains stable along mPC progression, supporting the use of diagnostic biopsies to guide poly (ADP-ribose) polymerase inhibitor treatment in metastatic castration-resistant prostate cancer. gLOH scores increase with emerging resistance to hormonal therapies, independently of individual HRR gene...

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Editorial Comment on Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

Nobumichi Tanaka is affiliated with an endowed chair funded by Nihon Medi‐Physics Co. Mariados N, Sylvester J, Shah D et al. Hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35795116/


Conclusion: Gathering and analyzing information concerning clinical experiences of hydrogel spacer can make a suitable indication and contra-indication criteria. Also, this effort must be necessary to achieve a safety use of hydrogel spacer and avoid severe adverse events in future.

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Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

1 Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan. 2 Departments of Radiology Kanazawa University Graduate School of Medical Science Kanazawa ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35795104/


Conclusions: Herein, we report the first case of ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer.

Mikhail Imseis from Clinical Oncology Forum, Prostate Cancer Connect Commented on a Post
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PARP inhibitors for the treatment of prostate cancer

Olaparib (Lynparza) and rucaparib (Rubraca) are both PARP inhibitors approved for mCRPC patients following AR therapy. Olaparib was the first PARP inhibitor approved, allowing it to gain a lead in the market, after the patients in the treatment arm of the Phase III PROpel trial achieved a median OS of 19.1 months and an rPFS of 5.8 months in the overall homologous recombination repair deficient cohort. Rucaparib received approval following positive results from the Phase II TRITON2 trial, where patients with measurable disease and BRCA mutations achieved a median ORR of 43.5% after rucaparib treatment.

Two other PARP inhibitors are currently in development for prostate cancer: talazoparib (Talzenna) and niraparib (Zejula). Neither therapeutics have late-phase data available in this indication, but talazoparib -treated patients with BRCA mutations in the Phase II TALAPRO-1 trial showed an rPFS of 9.3 months, whilst niraparib-treated patients had an rPFS of 8.2 months and an OS of 12.6 months in the Phase II GALAHAD trial.

Share your thoughts on the efficacy shown by both talazoparib and niraparib, and based on this data, if either drug is approved, how would this likely change your prescribing practices?

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  • from Clinical Oncology Forum July 13, 2022
    Paribs are used to treat prostate cancer but those last 2 meds are still being studied talazoparib is now being used for Rx of breast Ca So the Jury Show More
  • July 11, 2022
    What are the perceived benefits/drawbacks of talazoparib and niraparib?
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Erectile dysfunction following hydrogel injection and hypofractionated radiotherapy for prostate cancer: Our experience in 56 cases - PubMed

1 Urology Unit, Cannizzaro Hospital, Catania. [email protected] 2 Radiotherapy Unit, Cannizzaro Hospital, Catania. [email protected] 3 Urology Unit, Cannizzaro Hospital, Catania. [email protected] 4 Urology Unit, Cannizzaro Hospital, Catania. [email protected] 5 Radiotherapy ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35775340/


Conclusions: The use of hydrogel injection and intraprostatic fiducials followed by HRT allowed to kept pretreatment sexual potency in 62.5% of the cases.

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Modifiable risk factors for prostate cancer in low- and lower-middle-income countries: a systematic review and meta-analysis - PubMed

In LIC and LMIC, high fat intake was associated with higher risk of PCa while a diet rich in vegetables and tea intake was associated with a lower risk. Future ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35790786/


Conclusions: In LIC and LMIC, high fat intake was associated with higher risk of PCa while a diet rich in vegetables and tea intake was associated with a lower risk. Future prospective studies will be important to elucidate whether other modifiable risk factors for PCa specific to LIC and LMIC can be identified to inform impactful and...

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Development and validation of a multivariable prognostic model in de novo metastatic castrate sensitive prostate cancer - Prostate Cancer and Prostatic Diseases

Metastatic castrate sensitive prostate cancer (mCSPC) is a heterogeneous disease state with variable prognosis. Although several life-prolonging systemic agents are available, there is no robust multivariable model to predict prognosis ..... see more

Source : https://www.nature.com/articles/s41391-022-00560-3


Conclusions: A prognostic model for men with de novo mCSPC was developed and validated in an independent testing set. Our model had high accuracy for predicting OS and rPFS. The model includes commonly used clinical and laboratory parameters and can guide risk stratification of these patients for participation in future trials.