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Malayoside, a Cardenolide Glycoside Extracted from Antiaris Toxicaria Lesch, Induces Apoptosis in Human Non-small Lung Cancer Cells via MAPK-Nur77 Signaling Pathway - PubMed

Malayoside, a Cardenolide Glycoside Extracted from Antiaris Toxicaria Lesch, Induces Apoptosis in Human Non-small Lung Cancer Cells via MAPK-Nur77 Signaling Pathway - PubMed

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https://pubmed.ncbi.nlm.nih.gov/34043967/

Lung cancer is the leading cause of cancer deaths in the world. Non-small cell lung cancer (NSCLC), with poor prognosis and resistance to chemoradiotherapy, is the most common histological type of lung cancer. Therefore, it is necessary to develop new and more effective treatment strategy for NSCLC. ...

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    Key Points
    • In the current study involving cell line, researchers demonstrated that the apoptotic effect of malayoside resulted from the induction of Nur77 expression, cytoplasmic localization, and mitochondrial targeting.
    • Nur77 is an orphan member of the nuclear receptor superfamily, and plays an important role in cell proliferation, differentiation, inflammation, survival, and apoptosis in NSCLC and other cancers.
    • Importantly, the activation of the Nur77 apoptotic pathway by malayoside was tied to its activation of p38α and ERK1/2; the inhibition of p38α and ERK1/2 stymied the ability of malayoside to induce Nur77 expression and apoptosis..
    • The authors concluded, “Our findings provide new insight into the mechanism by which p38 and ERK1/2 mediate the apoptotic effects of diverse chemotherapeutic agents for NSCLC. Moreover, other studies have reported that malayoside is less toxic to the heart and has a higher therapeutic index than ouabain [39]. Thus, malayoside may be a potential anti-cancer agent with high efficiency and low toxicity. In a word, malayoside represents a promising agent for NSCLC therapy that warrants further clinical development.”