Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33082208/

Through the use of SPPs, we were able to offer combination therapy targeting MET -amplified resistance identified on the first-in-human study of selpercatinib. These data suggest that MET dependence is a recurring and potentially targetable mechanism of resistance to selective RET inhibition i ...