Comparison of 22C3-PD-L1 Expression Between Paired Tumor... : Applied Immunohistochemistry & Molecular Morphology
ion. A total of 460 paired paraffin blocks of surgical NSCLC specimens were analyzed using the 22C3-PD-L1 assay. PD-L1 expression between 2 paired paraffin blocks was calculated using 3 classification schemes, tumor proportion score (TPS)-based 3-level classification and TPS-based binary classification using TPS ≥1% or TPS ≥50% as the cutoff.
Conclusions: In cases that harbored different morphology in different paraffin blocks, the dual-block immunohistochemistry assessment method is recommended due to the intratumoral heterogeneity.
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Albert DekkerNovember 25, 2022We know that tumors are heterogeneous but in real life how many blocks will you test