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• In the current study, the authors analyzed characteristics of patients treated with tyrosine kinase inhibitors (TKIs) with either de novo or secondary metastatic EGFR NSCLC.
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De Novo Versus Secondary Metastatic EGFR-Mutated Non-Small-Cell Lung Cancer - PubMed

Despite the survival advantage reported in the pre-TKI era for relapsed NSCLC, molecular features and outcome of TKI-treated metastatic EGFR + tumors are currently independent of preceding nonmetastatic disease. This ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33898315/

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Data Integration to Improve Real-world Health Outcomes Research for Non-Small Cell Lung Cancer in the United States: Descriptive and Qualitative Exploration - PubMed

The management of patients with NSCLC requires care from a multidisciplinary team, leading to a lack of a single aggregated data source in real-world settings. The availability of integrated clinical ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33843600/

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    Key Points • In the current retrospective study, the researchers integrated data from several complementary sources to facilitate health outcomes research in patients with non-small cell lung cancer (NSCLC). These sources Show More
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65-Year-Old Man with Rare Presentation of Lung Cancer

A 65-year-old male with a 40 pack-year smoking history presents with a dry cough that is sometimes accompanied by ..... see more

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Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer - PubMed

doi: 10.1080/01902148.2021.1885525. Online ahead of print. 1 Department of Surgery, Thoracic Oncology Program, University of California, San Francisco, San Francisco, California, USA. Purpose: Non-small lung (NSCLC) is the deadliest cancer, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33908819/

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Real-world characteristics and outcomes of advanced non-small-cell lung cancer patients with EGFR exon 19 deletions or exon 21 mutations - PubMed

Aim: To estimate real-world (rw) outcomes for first-line therapy in patients with advanced EGF receptor ( EGFR)-mutated non-small-cell lung cancer (NSCLC), focusing on specific mutation types. Patients & methods: Retrospective ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33866796/

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RELAY, ramucirumab plus erlotinib versus placebo plus erlotinib in patients with untreated, EGFR-mutated, metastatic non-small cell lung cancer: Europe/United States subset analysis - PubMed

doi: 10.1016/j.ctarc.2021.100378. Online ahead of print. 1 Hospital doce de Octubre, Medical Oncology Department Thoracic Cancer and Early Drug Development Unit, Madrid, Spain. Electronic address: sponceaix@gmail.com. 2 Department of Oncology, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33905962/

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    What are your perceptions of patient access to biomarker testing? Please share.
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Key Points
• In this unusual case, a 42-year-old woman presented with general malaise and anorexia for the past 3 months. The initial evaluation indicated advanced right upper lung ..... see more

Successful management of a lung cancer patient harbouring both EGFR mutation and EML4-ALK fusion gene with disseminated intravascular coagulation - PubMed

doi: 10.1016/j.rmcr.2021.101393. 1 Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa-Mukaihata, Fushimi-Ku, Kyoto, Japan. 2 Department of Respiratory Medicine, Ijinkai Takeda General ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33854939/

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    Key Points • In this unusual case, a 42-year-old woman presented with general malaise and anorexia for the past 3 months. The initial evaluation indicated advanced right upper lung cancer with multiple Show More
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Utility of Circulating Tumor DNA in Identifying Somatic Mutations and Tracking Tumor Evolution in Patients with Non-small Cell Lung Cancer - PubMed

Although ctDNA exhibited similar utility to tissue biopsies, more mutations in targetable genes were missed in tissue biopsies. Therefore, the evaluation of ctDNA in conjunction with tissue biopsies may help ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33878340/

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    Key Points • In this retrospective study, researchers compared the utility of circulating tumor DNA (ctDNA) and solid tumor biopsy in non-small cell lung cancer. They assessed the usefulness of ctDNA in Show More
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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing - PubMed

The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on the accurate determination of the genomic status of the tumour. For this reason, molecular ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33875457/

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Addition of Nivolumab to Neoadjuvant Chemotherapy in Resectable Stage IIIA NSCLC

In the Spanish phase II NADIM trial reported in The Lancet Oncology , Provencio et al found that the addition of nivolumab to neoadjuvant chemotherapy and the use of adjuvant ..... see more

Source : https://ascopost.com/news/october-2020/addition-of-nivolumab-to-neoadjuvant-chemotherapy-in-resectable-stage-iiia-nsclc/

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Utility of Circulating Tumor DNA in Identifying Somatic Mutations and Tracking Tumor Evolution in Patients with Non-small Cell Lung Cancer - PubMed

Although ctDNA exhibited similar utility to tissue biopsies, more mutations in targetable genes were missed in tissue biopsies. Therefore, the evaluation of ctDNA in conjunction with tissue biopsies may help ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33878340/

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Key Points
• In this retrospective study, researchers assessed how allelic frequency relates to survival in patients with EGFR mutant non-small cell lung cancer (NSCLC). The investigators conflated allelic ..... see more

The Impact of Variant Allele Frequency in EGFR Mutated NSCLC Patients on Targeted Therapy - PubMed

EGFR mutations represent the most common currently targetable oncogenic driver in non-small cell lung cancer. There has been tremendous progress in targeting this alteration over the course of the last ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33869038/

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• The authors of this narrative review explored the most important predictive biomarkers in advanced non-small cell lung cancer (NSCLC). Here are their results with respect to ..... see more

Non-small cell lung cancer molecular characterization of advanced disease with focus on sex differences: a narrative review

Non-small cell lung cancer molecular characterization of advanced disease with focus on sex differences: a narrative review see more

Source : https://pcm.amegroups.com/article/view/6062

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Non-small cell lung cancer with MET exon 14 skipping alteration responding to immunotherapy: a case report - PubMed

Immunotherapy has been proved to be a promising candidate for advanced non-small cell lung cancer (NSCLC). Despite MET mutations are regarded as an independent factor of programmed death ligand 1 ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33842645/

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    Key Points • Case study indicating that NSCLC with METex14 had a significant response to anti-PD-1 therapy. Even though targeted therapy has become the mainstay regimen of NSCLC with METex14, treatment-resistant genes Show More
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CircRNA_100395 Carried by Exosomes From Adipose-Derived Mesenchymal Stem Cells Inhibits the Malignant Transformation of Non-Small Cell Lung Carcinoma Through the miR-141-3p-LATS2 Axis - PubMed

doi: 10.3389/fcell.2021.663147. 1 Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2 Department of Medical Oncology, Shulan (Hangzhou) Hospital, Affiliated to Shulan International ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33842488/

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The Fusion Gene Landscape in Taiwanese Patients with Non-Small Cell Lung Cancer - PubMed

1 Epigenome Research Center, China Medical University Hospital, Taichung 404332, Taiwan. 2 Department of Laboratory Medicine, China Medical University Hospital, Taichung 404332, Taiwan. 3 Center for Precision Medicine, China Medical ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33809651/

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Non-small cell lung cancer with MET exon 14 skipping alteration responding to immunotherapy: a case report - PubMed

Immunotherapy has been proved to be a promising candidate for advanced non-small cell lung cancer (NSCLC). Despite MET mutations are regarded as an independent factor of programmed death ligand 1 ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33842645/

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Neoadjuvant Nivolumab plus Chemotherapy Increased Pathological Complete Response Rate in CheckMate-816 Lung Cancer Trial | AACR | News Releases

PHILADELPHIA - Adding nivolumab (Opdivo) to chemotherapy as neoadjuvant treatment for patients with resectable non-small cell lung cancer (NSCLC) produced significant improvement of pathological complete response (pCR, primary endpoint) rate ..... see more

Source : https://www.aacr.org/about-the-aacr/newsroom/news-releases/neoadjuvant-nivolumab-plus-chemotherapy-increased-pathological-complete-response-rate-in-checkmate-816-lung-cancer-trial/

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Extensive-Stage Small Cell Carcinoma Transformation From EGFR Del19-Mutant Lung Adenocarcinoma on Gefitinib at the Twelfth-Year Follow-Up Case Report - PubMed

We report about SCCT that occurred 45 months after the initial diagnosis of ADC in an East Asian never-smoker woman with advanced-stage EGFR Del-19-mutant lung ADC treated with combined chemoradiotherapy ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33816221/