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Prediction Model for Tumor Volume Nadir in EGFR-mutant NSCLC Patients Treated With EGFR Tyrosine Kinase Inhibitors - PubMed

doi: 10.1097/RTI.0000000000000615. Online ahead of print. 1 Departments of Imaging Medical Oncology, Dana Farber Cancer Institute Departments of Radiology Medicine, Brigham and Women's Hospital Department of Biostatistics, Harvard Chan School ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34524205/

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The value of innovation: association between improvements in survival of advanced and metastatic non-small cell lung cancer and targeted and immunotherapy - PubMed

doi: 10.1186/s12916-021-02070-w. 1 F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland. [email protected] 2 PHMR Ltd., Westport, Ireland. 3 F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland. 4 Roche ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34521405/

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    Key Points • Conclusion/Relevance: “Our findings expand on the SEER data and provide additional evidence suggesting improvements in survival of patients with advanced and metastatic NSCLC over the past decade could be Show More
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Patient-Reported Outcomes with Selpercatinib Among Patients with RET Fusion-Positive Non-small Cell Lung Cancer in the Phase 1/2 LIBRETTO-001 Trial - PubMed

Patients with non-small cell lung cancer (NSCLC) generally experience greater symptom burden and lower health-related quality of life (HRQoL) as disease progresses. In a phase 1/2 trial, improvements in HRQoL ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34523767/

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    Key Points • Conclusion/Relevance: “In this interim analysis, the majority of patients with RET fusion-positive NSCLC remained stable or improved on all QLQ-C30 subscales at each study visit, demonstrating the favorable Show More
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Methods for actionable gene fusion detection in lung cancer: now and in the future - PubMed

Although gene fusions occur rarely in non-small-cell lung cancer (NSCLC) patients, they represent a relevant target in treatment decision algorithms. To date, immunohistochemistry and fluorescence in situ hybridization are the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34525844/

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Real-world evaluation of second line chemotherapy for patients with advanced non-small cell lung cancer harboring preexisting interstitial lung disease - PubMed

Twenty-four patients with a median age of 71 years who were treated between April 2013 and March 2021 were included. The response rate after second-line chemotherapy with S-1 (n = ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34415485/

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β-elemene inhibits non-small cell lung cancer cell migration and invasion by inactivating the FAK-Src pathway - PubMed

Despite sustained effort, the prognosis of lung cancer remains poor and the therapeutic responses are limited. Cell movement ability is a prerequisite for lung cancer metastasis, which involves focal adhesion ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34504549/

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Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer - PubMed

Inhibin βA (INHBA) serves a prognostic and tumor‑promoting role in numerous types of cancer. The present study aimed to determine the clinical significance of INHBA in non‑small cell lung cancer ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34505633/

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RET Inhibitors in Non-Small-Cell Lung Cancer - PubMed

RET rearrangements are observed in 1-2% of non-small-cell lung cancer (NSCLC) patients and result in the constitutive activation of downstream pathways normally implied in cell proliferation, growth, differentiation and survival. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34503226/

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Targeted Therapy for RET Fusion Lung Cancer: Breakthrough and Unresolved Issue - PubMed

Molecular drugs targeting mutated or rearranged oncogene drivers have become one of the standard recognized treatments in patients with advanced and recurrent non-small cell lung cancer. RET is located in ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34497761/

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Hallmarks of RET and Co-occuring Genomic Alterations in RET-aberrant Cancers - PubMed

doi: 10.1158/1535-7163.MCT-21-0329. Online ahead of print. 1 Department of Internal Medicine, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 2 H. Lee Moffitt ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34493590/

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ABCB1 and ABCG2, but not CYP3A4 limit oral availability and brain accumulation of the RET inhibitor pralsetinib - PubMed

SLCO1A/1B and CYP3A4 are unlikely to affect the pharmacokinetics of pralsetinib, but ABCG2 and especially ABCB1 markedly limit its brain and testis penetration, as well as oral availability. These effects ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34450308/

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Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development - PubMed

Rearranged during transfection (RET) is a receptor tyrosine kinase essential for the normal development and maturation of a diverse range of tissues. Aberrant RET signaling in cancers, due to RET ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34402300/

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How clinically useful is comprehensive genomic profiling for patients with non-small cell lung cancer? A systematic review - PubMed

Given the lack of a gold standard, the clinical usefulness of Comprehensive Genomic Profiling (CGP) has not been established. This systematic review aimed to evaluate evidence about the clinical benefit ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34461270/

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BRD7 increases resistance to EGFR tyrosine kinase inhibitor (EGFR-TKI) in non-small cell lung cancer - PubMed

doi: 10.23736/S0026-4806.21.07716-8. Online ahead of print. 1 Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34477353/

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Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer - PubMed

The ALI score is a powerful prognostic and predictive biomarker for patients with advanced NSCLC treated with PD-L1 inhibitors alone, but not in combination with chemotherapy. Its association with outcomes ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34481329/

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Viral Infection and Lung Cancer Immunotherapy - PubMed

Immunotherapy with immune checkpoint inhibitors (mainly anti-PD1 and anti-PDL1 monoclonal antibodies) became a standard of care in non-small cell lung cancer (NSCLC) patients. Most of the clinical trials excluded patients ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34434887/

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Inhibition of miR-144-3p exacerbates non-small cell lung cancer progression by targeting CEP55 - PubMed

Increasing evidence has indicated that microRNA dysregulation is closely related to the occurrence and development of cancers. Herein, we investigated the relationship between miR-144-3p and CEP55 expression. We then evaluated ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34435195/

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CircRNA (circ_0008057) promotes uremic serum-mediated proliferation and migration of vascular smooth muscle cells via miR-370/PLk1 signaling pathway - Biolife - Scientific Publisher

1 Department of Intensive-care Unit, Dongying Victory Hospital Intensive-care Unit, Dongying, China. 2 Department of Urology, Dongying Victory Hospital, Dongying, China. 3 Department of Cardiovascular Medicine, Dongying Victory Hospital, Dongying, ..... see more

Source : https://www.biolifesas.org/biolife/2021/03/10/circrna-circ_0008057-promotes-uremic-serum-mediated-proliferation-and-migration-of-vascular-smooth-muscle-cells-via-mir-370-plk1-signaling-pathway/

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Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers - PubMed

ALK, ROS1, and RET kinase fusions are important predictive biomarkers of tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). Analysis of cell-free DNA (cfDNA) provides a noninvasive method to ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34310819/

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Multi- class classification of breast cancer abnormalities using Deep Convolutional Neural Network (CNN) - PubMed

The real cause of breast cancer is very challenging to determine and therefore early detection of the disease is necessary for reducing the death rate due to risks of breast ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34437623/