CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36026440/
Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors (ICIs) are only efficacious for a subset of patients. To gain a better understanding of the antitumor immune response in breast cancer, we examined the heterogeneity of CD8 + T cells in tumors, metasta ...
Conclusion: Our study indicates that CD39 TRM cells with a clonal overlap across compartments are key players in antitumor immunity in breast cancer.