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The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature - PubMed

The use of the PARP inhibitors (PARPi) in the treatment of breast cancer (BC) with germine mutations has evolved over the years, and further research has been done in order ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33767780/

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Circulating tumor cells and palbociclib treatment in patients with ER-positive, HER2-negative advanced breast cancer: results from a translational sub-study of the TREnd trial

Background Circulating tumor cells (CTCs) are prognostic in patients with advanced breast cancer (ABC). However, no data exist about their use in patients treated with palbociclib. We analyzed the prognostic ..... see more

Source : https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-021-01415-w

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Prognostic value of molecular classification in metastatic breast cancer confirmed

Barcelona researchers at the Hospital Clínic-IDIBAPS Research Institute, the University of Barcelona and the SOLTI academic cancer research group have shown that the molecular classification of breast cancer, which divides ..... see more

Source : https://www.eurekalert.org/pub_releases/2021-03/uob-pvo032921.php

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Breast Cancer Patients: A Population-Based Analysis

If the address matches an existing account you will receive an email with instructions to reset your password. see more

Source : https://www.liebertpub.com/doi/10.1089/whr.2020.0094

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Management of Abemaciclib‐Associated Adverse Events in Patients with Hormone Receptor‐Positive, Human Epidermal Growth Factor Receptor 2‐Negative Advanced Breast Cancer: Safety Analysis of MONARCH 2 and MONARCH 3

Abemaciclib demonstrated efficacy in hormone receptor‐positive, human epidermal growth factor receptor 2‐negative advanced breast cancer. Here we provide a comprehensive summary of the most common adverse events (AEs), their management, ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794176/

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Abemaciclib in combination with endocrine therapy for East Asian patients with HR+, HER2‐ advanced breast cancer: MONARCH 2 & 3 trials

This post‐hoc analysis of MONARCH 2 and MONARCH 3 assesses the efficacy, safety, and pharmacokinetics (PK) of abemaciclib in combination with endocrine therapy (ET) in East Asian patients with hormone ..... see more

Source : https://onlinelibrary.wiley.com/doi/10.1111/cas.14877

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Detonating fuse for breast cancer discovered

Targeted treatment of basal-like breast cancer could be facilitated by YAP inhibitors in the future. As reported by an MDC team headed by Walter Birchmeier in the scientific journal Cancer ..... see more

Source : https://eurekalert.org/pub_releases/2021-03/mdcf-dff032221.php

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Oncology trends: Breast cancer leads Twitter mentions in Q4 2020

The top tweeted terms are the trending industry discussions happening on Twitter by key individuals (influencers) as tracked by the platform. Covid-19 leading to delay in cancer diagnoses, the road ..... see more

Source : https://www.pharmaceutical-technology.com/features/oncology-trends-breast-cancer/

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Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial

Despite therapeutic advances in HER2-positive metastatic breast cancer, resistance to trastuzumab inevitably develops. In the PHOEBE study, we aimed to assess the efficacy and safety of pyrotinib (an irreversible pan-HER ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S1470204520307026

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Clinical Outcomes With Abemaciclib After Prior CDK4/6 Inhibitor Progression in Breast Cancer: A Multicenter Experience

Background: Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) are widely used as first-line therapy for hormone receptor-positive metastatic breast cancer (HR+ MBC). Although abemaciclib monotherapy is also FDA-approved for ..... see more

Source : https://jnccn.org/view/journals/jnccn/aop/article-10.6004-jnccn.2020.7662/article-10.6004-jnccn.2020.7662.xml

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Atezolizumab and nab-Paclitaxel in Advanced Triple-Negative Breast Cancer: Biomarker Evaluation of the IMpassion130 Study - PubMed

doi: 10.1093/jnci/djab004. Online ahead of print. 1 University of Pittsburgh Medical Center, Hillman Cancer Center/Magee Women's Hospital, Pittsburgh, PA. 2 Genentech, Inc., South San Francisco, CA. 3 Peter MacCallum Cancer ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33523233/

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Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer - PubMed

Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating in abundant extracellular mucin and can be classified into paucicellular (Type A) and hypercellular (Type B) subtypes. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33732635/

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Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk - PubMed

High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33733051/

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Vascular Inflammation and Cardiovascular Burden in Metastatic Breast Cancer Female Patients Receiving Hormonal Treatment and CDK 4/6 Inhibitors or Everolimus - PubMed

doi: 10.3389/fcvm.2021.638895. 1 Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. 2 Experimental Surgery and Translational Research, Biomedical Research Foundation Academy ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33732735/

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Impact of adjuvant endocrine therapy in older patients with comorbidities and estrogen receptor-positive, node-negative breast cancer-a National Cancer Database analysis - PubMed

In older patients who have pN0, ER-positive/HER2-negative breast cancer with comorbidities, adjuvant ET was associated with improved OS, which may have been overestimated given the confounders inherent in observational studies. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33735487/

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64-Year-Old Female with Palatable Lump in Left Breast

A 64-year-old woman is referred to an oncology clinic after discovering a palatable lump in her left breast about ..... see more

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  • 1 month 1 week
    I agree with my colleagues and would start her on an AI and a CDK 4/6 inhibitor.
  • 1 month 1 week
    I would start treatment with Letrozole + Ribociclib. Ribociclib with an AI is supported by RCT phase III trial.
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Abstract PS17-02: Molecular alterations in the androgen receptor and associated clinical outcomes in hormone receptor-positive/HER2- metastatic breast cancer

Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas Background: Although the androgen receptor (AR) is frequently co-expressed with ER and PR in hormone receptor-positive ..... see more

Source : https://cancerres.aacrjournals.org/content/81/4_Supplement/PS17-02

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Abstract PS2-10: Circulating tumor DNA (ctDNA) as a diagnostic tool to identify putative germline BRCA mutations

Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas Background: As the role of precision medicine in metastatic breast cancer (MBC) expands, there is an ..... see more

Source : https://cancerres.aacrjournals.org/content/81/4_Supplement/PS2-10