Hallmarks of cancer in canine mammary tumors: Insights into a potential model for human triple-negative breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41654097/
Human breast cancer (HBC) is a complex disease with several molecular subtypes, posing challenges in diagnosis and treatment. Among these subtypes, triple-negative breast cancer (TNBC) is particularly challenging due to...
Review compares cancer hallmarks in canine mammary carcinomas and human triple-negative breast cancer, highlighting biological parallels, model potential, and translational challenges, supporting comparative oncology and future personalized therapeutic research efforts.
Case Report: Comparison different response after neoadjuvant chemotherapy of the breast with cell-in-cell-report of two cases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41641261/
Neoadjuvant chemotherapy (NACT) is commonly applied in human epidermal growth factor receptor 2 (HER2)-positive breast cancer to reduce tumor size and increase the likelihood of breast-conserving surgery. However, predictive markers...
Two HER2-positive breast cancer cases showed contrasting responses to neoadjuvant chemotherapy; changes in cell-in-cell structures correlated with treatment response, suggesting CIC dynamics may serve as potential predictive markers.
Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41596562/
Cyclodextrins (CyDs) are cyclic oligosaccharides that form inclusion complexes that allow organic compounds and other substances to be incorporated into their cavities. Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is frequently used to improve the...
Review highlights hydroxypropyl-β-cyclodextrin enhancing solubility, delivery, and efficacy of anticancer drugs, with emerging roles as an active agent via targeted delivery and autophagy-mediated mechanisms.
Pembrolizumab-Induced Colitis With Concurrent Capecitabine in Triple-Negative Breast Carcinoma: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41523718/
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but their use is associated with immune-related adverse events (irAEs). Colitis is a significant irAE, particularly with programmed cell death protein 1...
Case report describes pembrolizumab-induced colitis during concurrent capecitabine in triple-negative breast cancer, highlighting diagnostic challenges, importance of histologic confirmation, and need for early recognition and management of immune-related colitis.
Genetic Testing for All Breast Cancer Patients: The GET FACTS Randomized Clinical Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41525075/
ClinicalTrials.gov Identifier: NCT04245176.
This randomized trial showed personalized genetic risk counseling improved contralateral breast cancer risk understanding but did not change contralateral prophylactic mastectomy decisions, supporting informed discussions without influencing surgical choice.