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Pembrolizumab-Induced Colitis With Concurrent Capecitabine in Triple-Negative Breast Carcinoma: A Case Report - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41523718/

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but their use is associated with immune-related adverse events (irAEs). Colitis is a significant irAE, particularly with programmed cell death protein 1...

Case report describes pembrolizumab-induced colitis during concurrent capecitabine in triple-negative breast cancer, highlighting diagnostic challenges, importance of histologic confirmation, and need for early recognition and management of immune-related colitis.

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Genetic Testing for All Breast Cancer Patients: The GET FACTS Randomized Clinical Trial - PubMed

Genetic Testing for All Breast Cancer Patients: The GET FACTS Randomized Clinical Trial - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41525075/

ClinicalTrials.gov Identifier: NCT04245176.

This randomized trial showed personalized genetic risk counseling improved contralateral breast cancer risk understanding but did not change contralateral prophylactic mastectomy decisions, supporting informed discussions without influencing surgical choice.

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SABCS 2025: Practice-Changing Trials and Evolving Standards in Breast Cancer Care

In this SABCS 2025 conference video, Dr. Virginia Kaklamani, Professor of Medicine at UT Health San Antonio and Co-Director of SABCS, discusses key advances shaping contemporary breast cancer care. Highlights include emerging applications of artificial intelligence in breast cancer management, findings from the HER2-CLYMO5 trial supporting chemotherapy de-escalation with tucatinib, and promising phase 3 data evaluating the oral selective estrogen receptor degrader giredestrant.

Dr. Isabel Bedrosian, Professor of Breast Surgical Oncology at MD Anderson Cancer Center, reviews results from the Alliance A11104 trial, which demonstrated that routine preoperative breast MRI did not improve locoregional control or survival in patients with early-stage breast cancer. These findings reinforce evidence-based surgical decision-making and support a more selective approach to preoperative imaging.

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Salivary Gland Secretory Carcinoma in the Facial Region: A Pediatric Case Presentation - PubMed

Salivary Gland Secretory Carcinoma in the Facial Region: A Pediatric Case Presentation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41487862/

Salivary gland secretory carcinoma (SC) represents a rare, slow-growing, low-grade malignant neoplasm that occurs mainly in the parotid gland. It has a slight predilection for the male gender and usually...

Pediatric case report describes rare salivary gland secretory carcinoma presenting as a painless facial mass in a child, emphasizing diagnostic consideration of this low-grade malignancy beyond typical adult populations.

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Challenges in Meeting Dose Constraints During Left Postmastectomy Radiotherapy in a Patient With a Leadless Pacemaker - PubMed

Challenges in Meeting Dose Constraints During Left Postmastectomy Radiotherapy in a Patient With a Leadless Pacemaker - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41458719/

A 60-year-old woman with a 20-year history of cardiac pacing presented with node-positive left breast cancer and underwent total mastectomy. Postmastectomy radiotherapy (PMRT) was indicated; however, because a subcutaneous pacemaker...

Case report highlights challenges achieving pacemaker dose constraints during left postmastectomy radiotherapy, showing that leadless pacemaker implantation alone may not prevent excessive radiation exposure without careful treatment planning.