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Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma - PubMed

Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34969327/

doi: 10.1080/10428194.2021.2020782. Online ahead of print. 1 Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 2 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.



Conclusion/Relevance: The beneficial effect of statins on the anti-lymphoma activity of the rituximab-based chemotherapy regimen is controversial. Here, we retrospectively reviewed patients with naïve-treated advanced diffuse large B-cell lymphoma (DLBCL) receiving frontline R-CHOP, and for whom data regarding differential statins use was available at the time of initiation of treatment. We observe that patients treated with statins and R-CHOP experienced a significantly higher CR rate as compared to those who received R-CHOP only.