Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma
Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2021.2003533
ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy arising from germinal center or post-germinal center B-cells that retain many of the properties of normal B-cells. Here we show that a subset of DLBCL express the cytokine IL-10 and its receptor.
Conclusion/Relevance: In this work, we demonstrate that (1) the expression of IL-10 and IL-10R is a hallmark of DLBCL and strongly correlated with STAT3 phosphorylation and with MYD88/BCR mutations in DLBCL cell lines and DLBCL patients, that (2) IL-10 signaling is cell-intrinsically required for DLBCL growth in ectopic and orthotopic xenotransplantation models and that (3) the tumor-cell-intrinsic expression of IL-10 serves the additional purpose of suppressing immunity through a mechanism likely involving the recruitment or local retention of regulatory T-cells.