Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34739844/

In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene expression subgroup rely upon chronic active B cell receptor signaling for viability, a dependency that is targetable by ibrutinib. A phase III trial ("Phoenix;" ClinicalTrials.gov: NCT01855750) showed a survival ...