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Diagnostic accuracy of pelvic magnetic resonance imaging for the assessment of bone marrow involvement in diffuse large B-cell lymphoma - PubMed

Diagnostic accuracy of pelvic magnetic resonance imaging for the assessment of bone marrow involvement in diffuse large B-cell lymphoma - PubMed

Source :

https://pubmed.ncbi.nlm.nih.gov/34043683/

Pelvic MRI is effective for detecting BMinv in DLBCL patients, providing a more accurate indication of PFS than BMB/BMS and PET/CT do. It may ultimately be used to improve the accuracy of clinical staging, guide patient treatment, and evaluate prognosis.

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    Key Points
    • In the current retrospective study, Chinese investigators assessed the efficacy of pelvic magnetic resonance imaging (MRI) in the diagnosis of bone marrow involvement (BMinv) in 171 patients with diffuse large B-cell lymphoma (DLBCL).
    • Study participants had previously undergone bone marrow biopsy (BMB) and bone marrow smear (BMS), pelvic MRI, and whole-body positron emission tomography-computed tomography (PET/CT). BMB/BMS and whole-body PET/CT results were used as reference standards versus which the investigators calculated the diagnostic value of pelvic MRI for BMinv in the study population.
    • “The false negative rate for BMinv in DLBCL is higher with BMB/BMS than with pelvic MRI and PET/CT, and the latter two techniques have a high diagnostic value for BMinv,” the authors wrote. “Furthermore, pelvic MRI, as diagnostic tool for diagnosis of BMinv, has a higher predictive value of progression-free survival of patients than BMB/BMS and PET/CT has. At present, a combination of BMB/BMS and PET/CT is the standard method to evaluate BMinv.”
    • The authors concluded that “pelvic MRI may ultimately be used to improve the accuracy of clinical staging, guide patient treatment, and evaluate prognosis.”
    • In addition to its retrospective nature, another limitation of the current study was that the researchers did not assess the reproducibility of the pelvic MRI protocol for diagnosing BMinv on 1.5T MRI scanners.