The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914352/

Rationale: Primary central nervous system diffuse large B-cell lymphoma (PCNSL) is a rare and aggressive entity that resides in an immune-privileged site. The tumor microenvironment (TME) and the disruption of the immune surveillance influence lymphoma pathogenesis and immunotherapy resistance. Despite growing knowledge on heterogeneous therapeutic responses, no comprehensive description of the PCNSL TME is available.