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DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome - PubMed

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome - PubMed

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https://pubmed.ncbi.nlm.nih.gov/33951891/

DIS3 gene mutations (DIS3mts) occur in roughly 10% of multiple myeloma (MM) patients; furthermore, DIS3 expression could be affected by monosomy 13 or del(13q), which occur in approximately 40% of MM cases. Despite several reports on the prevalence of DIS3mts, their contribution to the pathobiology ...