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Cyclopamine sensitizes multiple myeloma cells to circularly permuted TRAIL-induced apoptosis - PubMed

Cyclopamine sensitizes multiple myeloma cells to circularly permuted TRAIL-induced apoptosis - PubMed

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https://pubmed.ncbi.nlm.nih.gov/33732371/

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a promising anti-myeloma drug prototype. The aim of the present study was to investigate the synergistic effects of cyclopamine and circularly permuted TRAIL (CPT) on the proliferation and apoptosis of multiple myeloma cells. The res ...

  • 3 weeks 2 days
    Interesting pharmacologic study demonstrating dual agent inhibition of myeloma cells. Further work hopefully will be done to confirm that this is a clinically relevant pathway