Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma

Source : https://www.researchsquare.com/article/rs-146899/v1

Osteolytic lesions (OL) characterize symptomatic multiple myeloma. The mechanisms of how malignant plasma cells (PC) cause OL in one region while others show no signs of bone destruction despite subtotal infiltration remain unknown. We report the first single-cell RNA sequencing (scRNA-seq) study...