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DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Source : https://link.springer.com/article/10.1186/s13148-020-00953-y

Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observed at particular regions of myeloma such as B cell-specific enhancers.