A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpression
Source : https://www.researchsquare.com/article/rs-94742/v1
A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpression Ke Yi, Hui Zhang, Yajun Zhang, Weijun Fu, Jian Hou, Rong Li Navy .....
Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma
Source : https://www.nature.com/articles/s41408-020-00377-0
Detecting persistent minimal residual disease (MRD) allows the identification of patients with an increased risk of relapse and death. In this study, we have evaluated MRD 3 months after transplantation .....
Multiple myeloma current treatment algorithms
Source : https://www.nature.com/articles/s41408-020-00359-2
The treatment of multiple myeloma (MM) continues to evolve rapidly with arrival of multiple new drugs, and emerging data from randomized trials to guide therapy. Along the disease course, the .....
Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma
Source : https://doi.org/10.1080/17474086.2020.1830372
Abstract Glucose-regulated protein 78 (GRP78) is a stress-inducible molecular chaperone expressed within the endoplasmic reticulum where it acts a master regulator of the unfolded protein response (UPR) pathway. At times .....
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
Source : https://www.nature.com/articles/s41419-020-03017-4
As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors .....
Lymphoma-like double-hit genetic abnormalities (MYC/IGH and IGH/BCL2) in a case of non-secretory multiple myeloma
Source : https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1821012
WHO classification of hematologic malignancies is based on a combination of: (1) clinical presentation; (2) morphologic findings; (3) immunophenotype of abnormal cells; and (4) presence of recurrent genetic abnormalities []. .....
Circulating miR‑451a levels as a potential biomarker to predict the prognosis of patients with multiple myeloma
Source : https://www.spandidos-publications.com/10.3892/ol.2020.12126
Introduction Multiple myeloma (MM) is an incurable cancer of plasma cells caused by the abnormal accumulation of monoclonal plasma cells in the bone marrow (BM) ( 1), which accounts for .....
Abstract PO-009: Cancer-related distress among multiple myeloma patients during the COVID-19 pandemic
Source : https://clincancerres.aacrjournals.org/content/26/18_Supplement/PO-009.abstract
AACR Virtual Meeting: COVID-19 and Cancer; July 20-22, 2020 Background: The rapid outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the delay of non-urgent or routine .....