Skip to main content
micro-community-banner
 
  • Saved

A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpression

A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpression

Source : https://www.researchsquare.com/article/rs-94742/v1

A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpression Ke Yi, Hui Zhang, Yajun Zhang, Weijun Fu, Jian Hou, Rong Li Navy .....

  • Saved

Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

Source : https://www.nature.com/articles/s41408-020-00377-0

Detecting persistent minimal residual disease (MRD) allows the identification of patients with an increased risk of relapse and death. In this study, we have evaluated MRD 3 months after transplantation .....

  • Saved


67-Year-Old Widow with Suspected Myeloma Relapse

Nancy, a 67-year-old widow, is a multiple myeloma patient who has been in partial remission for two years. When .....

  • Saved

53-Year-Old Male with Persistent Anemia


George is 53 and presents with complaints of persistent macrocytic anemia accompanied by mild thrombocytopenia. He says, “No one can find .....

  • Saved

Multiple myeloma current treatment algorithms

Multiple myeloma current treatment algorithms

Source : https://www.nature.com/articles/s41408-020-00359-2

The treatment of multiple myeloma (MM) continues to evolve rapidly with arrival of multiple new drugs, and emerging data from randomized trials to guide therapy. Along the disease course, the .....

  • Saved

Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma

Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma

Source : https://doi.org/10.1080/17474086.2020.1830372

Abstract Glucose-regulated protein 78 (GRP78) is a stress-inducible molecular chaperone expressed within the endoplasmic reticulum where it acts a master regulator of the unfolded protein response (UPR) pathway. At times .....

  • Saved

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf

Source : https://www.nature.com/articles/s41419-020-03017-4

As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors .....

  • Saved

Lymphoma-like double-hit genetic abnormalities (MYC/IGH and IGH/BCL2) in a case of non-secretory multiple myeloma

Lymphoma-like double-hit genetic abnormalities (MYC/IGH and IGH/BCL2) in a case of non-secretory multiple myeloma

Source : https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1821012

WHO classification of hematologic malignancies is based on a combination of: (1) clinical presentation; (2) morphologic findings; (3) immunophenotype of abnormal cells; and (4) presence of recurrent genetic abnormalities []. .....

  • Saved

Circulating miR‑451a levels as a potential biomarker to predict the prognosis of patients with multiple myeloma

Circulating miR‑451a levels as a potential biomarker to predict the prognosis of patients with multiple myeloma

Source : https://www.spandidos-publications.com/10.3892/ol.2020.12126

Introduction Multiple myeloma (MM) is an incurable cancer of plasma cells caused by the abnormal accumulation of monoclonal plasma cells in the bone marrow (BM) ( 1), which accounts for .....

  • Saved

Abstract PO-009: Cancer-related distress among multiple myeloma patients during the COVID-19 pandemic

Abstract PO-009: Cancer-related distress among multiple myeloma patients during the COVID-19 pandemic

Source : https://clincancerres.aacrjournals.org/content/26/18_Supplement/PO-009.abstract

AACR Virtual Meeting: COVID-19 and Cancer; July 20-22, 2020 Background: The rapid outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the delay of non-urgent or routine .....