Targeting RAS oncogenesis with SOS1 inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35101230/
RAS proteins play major roles in many human cancers, but programs to develop direct RAS inhibitors so far have only been successful for the oncogenic KRAS mutant G12C. As an alternative approach, inhibitors for the RAS guanine nucleotide exchange factor SOS1 have been investigated by several academi ...
Relevance: We summarize the current understanding of which combination partners may be most beneficial for patients with RAS driven tumors.