SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33859191/

SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model. Sod1 knockout markedly reduces tumor burden in vivo and ...