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Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation - PubMed

Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation - PubMed

Source :

https://pubmed.ncbi.nlm.nih.gov/33824136/

1 Massachusetts General Hospital. 2 Medical Oncology, Massachusetts General Hospital. 3 Department of Medicine, Massachusetts General Hospital. 4 Cancer Center, Massachusetts General Hospital. 5 Massachusetts General Hospital Cancer Center. 6 Medical Affairs, Guardant Health. 7 Cancer Center, Massachusetts General Hospital Cancer Center. 8 CCPO, Massachusetts General Hospital. 9 Oncology, Massachusetts General Hospital.