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Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Source :

https://www.nature.com/articles/s42003-021-01897-6

Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which is currently in clinical trials and may offer a potential avenue for treating aggressive NSCLC expressing mutated Kras.