Targeting KRAS: The Elephant in the Room of Epithelial Cancers - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33777798/

Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more than 90% in certain cancer types such as pancreatic adenocarcinoma. Although historically considered to be undruggable, a ...