The origins and genetic interactions of KRAS mutations are allele- and tissue-specific - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33753749/

Mutational activation of KRAS promotes the initiation and progression of cancers, especially in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific activating missense mutations. Although epidemiological studies connect specific alleles to clinical outcomes, the mec ...