Skip to main content
  • Saved

made a Post

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Source :

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009368

Author summary The diagnosis of a malignant tumor is preceded by a long process of tumor evolution, characterized by the gradual accumulation of driver mutations, genomic alterations that give cancer cells their typical growth advantage. This process is controlled by the immune system and understanding tumor-immune interactions is critical for the development of new anti-cancer therapies.