Skip to main content
  • Saved

made a Post

Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia

Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia

Source :

https://link.springer.com/article/10.1186/s13148-020-00979-2

Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from hematopoietic stem and progenitor cells (HSPCs). Patients with CMML are frequently treated with epigenetic therapeutic approaches, in particular the hypomethylating agents (HMAs), azacitidine (Aza) and decitabine (Dec). Although HMAs are believed to mediate their efficacy via re-expression of hypermethylated tumor suppressors, knowledge about relevant HMA targets is scarce.