Skip to main content
micro-community-banner
 
  • Saved

from Pathologist Connect made a Post

Sotorasib showed encouraging anticancer activity in patients with heavily pretreated advanced solid tumors harboring the KRAS p.G12C mutation. N Engl J Med 2020; 383:1207-1217

  • Saved

made a Post

Concomitant genetic alterations are associated with response to EGFR targeted therapy in patients with lung adenocarcinoma

Hualin Chen, 1 Meilian Liu, 1 Zhiwei Dai, 1 Shujun Li, 1 Yiping Luo, 1 Yongcun Wang, 1 Wenmei Su, 1 Weijing Cai, 2 Donghong Yang, 3 Jian Huang, 4 ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481595/

  • Saved

made a Post

PI3K-AKT-mTOR pathway alterations in advanced NSCLC patients after progression on EGFR-TKI and clinical response to EGFR-TKI plus everolimus combination therapy

Wenfeng Fang, 1, # Yihua Huang, 1, # Weiguang Gu, 2, 3, # Jiadi Gan, 1 Wenjing Wang, 4 Shiyue Zhang, 4 Kai Wang, 4 Jianhua Zhan, 1 Yunpeng Yang, ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481581/

  • Saved

made a Post

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Lung cancer is still the leading cause of death by cancer worldwide despite advances both in its detection and therapy. Multiple oncogenic driver alterations have been discovered, opening the prospective ..... see more

Source : https://www.nature.com/articles/s41417-020-00224-1

  • Saved

made a Post

Hormone gene signature guides a novel therapeutic opportunity to improve sensitivity to HER family inhibition in lung cancer

Lung cancer is the top cause of cancer-related deaths for both men and women in the United States and worldwide ( 1). Survival rates remain poor for lung cancer patients ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481617/

  • Saved

from Pathologist Connect made a Post

Nice editorial in The New England Journal of Medicine that “KRAS Is Indeed Druggable”

see more

www.nejm.org

Our apologies. An error occurred while setting your user cookie. Please set your browser to accept cookies to continue. NEJM.org uses cookies to improve performance by remembering your session ID ..... see more

Source : https://www.nejm.org/doi/full/10.1056/NEJMe2026372?query=recirc_curatedRelated_article

  • Saved

from Pathologist Connect made a Post

ESMO 2020: KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in early trial

see more

ESMO 2020: KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in early trial - ecancer

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical ..... see more

Source : https://ecancer.org/en/news/18665-esmo-2020-kras-inhibitor-sotorasib-appears-safe-achieves-durable-clinical-benefit-in-early-trial

  • Saved

from Pathologist Connect made a Post

An image of metastatic lung adenocarcinoma with a micropapillary pattern in an N2 mediastinal lymph node. Molecular pending. Any think it will have an actionable target?

  • Saved

made a Post

Analysis of KRAS mutations in circulating tumor DNA and colorectal cancer tissue

The mutation status of KRAS is important for anti-EGFR therapy in colorectal cancer (CRC) patients; however, detection of KRAS mutations in circulating tumor DNA (ctDNA) is problematic. We investigated tissue ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/10520295.2020.1810775

  • Saved

made a Post

The METeoric rise of MET in lung cancer

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.33159

  • Saved

made a Post

STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world

Background Mutations in STK11 (STK11m) and frequently co-occurring KRAS mutations (KRASm/STK11m) are associated with poor survival in metastatic NSCLC (mNSCLC) immuno-oncology trials. There are limited data regarding the prognostic significance ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238358

  • Saved

from Pathologist Connect made a Post

Here’s a clinical question:
Elderly smoker with a large lung mass and hilar adenopathy diagnosed as adenocarcinoma on EBUS. Patient has widespread metastases. Just enough tumor in the cell block ..... see more

63-Year-Old Female with Headaches and Visual Disturbances


A 63-year-old Caucasian female presented with headaches, visual problems, nausea, and fatigue. She has hyperlipemia and hypertension; both controlled ..... see more

  • Saved

from Commented on 's Post

Did you know there are currently 247 clinical trials looking at KRAS in the US? Results here

  • Saved

made a Post

The Level of Preoperative Plasma KRAS Mutations and CEA Predict Survival of Patients Undergoing Surgery for Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) belongs to the most common cancers. The liver is a predominant site of CRC dissemination. Novel biomarkers for predicting the survival of CRC patients with liver metastases ..... see more

Source : https://www.mdpi.com/2072-6694/12/9/2434

  • Saved

made a Post

Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors

Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has ushered in a new era of anti-tumor therapy, with sustained responses and significant survival advantages observed in multiple tumors, ..... see more

Source : https://link.springer.com/article/10.1186/s40364-020-00209-0

  • Saved

made a Post

Making NSCLC Crystal Clear: How Kinase Structures Revolutionized Lung Cancer Treatment

The parallel advances of different scientific fields provide a contemporary scenario where collaboration is not a differential, but actually a requirement. In this context, crystallography has had a major contribution ..... see more

Source : https://www.mdpi.com/2073-4352/10/9/725

  • Saved

from Pathologist Connect made a Post

Nice overview of most common RAS mutations. Reference: Front. Oncol., 18 October 2019

  • Saved

from Pathologist Connect made a Post

Do any of you have a separate molecular tumor board, or are NGS results woven into discussion during interdisciplinary conferences?