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2020 Association of Molecular Pathologists (AMP) Annual Meeting - A Review

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Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C-Mutant Non-Small Cell Lung Cancer

Purpose: KRAS is among the most commonly mutated oncogene in cancer including non-small cell lung cancer (NSCLC). In early clinical trials, inhibitors targeting G12C-mutant KRAS have achieved responses in some ..... see more

Source : https://clincancerres.aacrjournals.org/content/26/22/5962

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A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses

Cancer vaccines using synthetic long peptides (SLP) targeting tumor antigens have been tested in the clinic but the outcomes have been unimpressive, perhaps because these peptides elicit predominantly CD4+ T ..... see more

Source : https://www.nature.com/articles/s41541-020-00253-9

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The utility of sputum supernatant as an alternative liquid biopsy specimen for next-generation sequencing-based genomic profiling

Background Comprehensive mutation profiling has become a standard clinical practice in the management of advanced lung cancer. In addition to tissue and plasma, other body fluids are also being actively ..... see more

Source : https://www.researchsquare.com/article/rs-108555/v1

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58-Year-Old Female with Cough and Dyspnea

Ann is a 58-year old attorney. She presents to her primary care physician, complaining of a persistent cough and dyspnea. She ..... see more

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Check out the great lineup for next month at the Precision Medicine Leaders Summit Virtual Series - Pathology! I will be moderating a panel on KRAS. How Pathologists are crucial ..... see more

Coverage from the 2020 Association of Molecular Pathologists (AMP) Conference - November 19th, 2020

Coverage from the 2020 Association of Molecular Pathologists (AMP) Conference - November 18th, 2020

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Coverage from the 2020 Association of Molecular Pathologists (AMP) Conference - November 17th, 2020