Skip to main content
  • Saved

made a Post

Indirect impact of PD-1/PD-L1 blockade on a murine model of NK cell exhaustion

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2020.00007/abstract

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has shown unprecedented clinical benefits for many cancers, which have been attributed to the prevention of immune suppression and exhaustion with enhanced anti-tumor responses.

Sign In or Register Today to Access This Content