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Genetic Modification of CD8  T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Genetic Modification of CD8 T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Source : https://doi.org/10.3389/fimmu.2019.02990

Adoptive immunotherapy with ex vivo-expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with cancer. The failure of many patients to develop long-term tumor control may be, in part, due to exhaustion of transferred T cells in the presence of a hostile tumor microenvironment.

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