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Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy?

Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy?

Source : https://doi.org/10.3389/fimmu.2019.03004

Neoantigens derive from non-synonymous somatic mutations in malignant cells. Recognition of neoantigens presented via human leukocyte antigen (HLA) molecules on the tumor cell surface by T cells holds promise to enable highly specific and effective anti-cancer immune responses and thus neoantigens provide an exceptionally attractive target for immunotherapy.

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