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Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0747-1

The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs signatures and their role in tumor microenvironment.

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