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Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1673125

ABSTRACT The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endogenous CD8 T cell responses to MC-38 neo-antigens in tumor-bearing mice and after anti-PD-L1 checkpoint therapy.

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