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Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas

Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas

Source :

https://link.springer.com/article/10.1007/s00262-021-02883-x

The dynamics of PD-L1 expression are poorly understood over the development of lung adenocarcinomas from pre-invasive lesions to fully invasive carcinomas. Given the importance of PD-L1 expression for the selection of patients to receive immunotherapy in the metastatic setting and possibly in the neoadjuvant setting, we sought to evaluate the agreement of PD-L1 expression in invasive and lepidic components of resected tumor specimens.