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Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Source :

https://doi.org/10.3389/fonc.2020.617385

Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, which can determine tumor progression and therapy outcomes.