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Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse

Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse

Source :

https://doi.org/10.1080/2162402X.2020.1841392

ABSTRACT Therapeutic cancer vaccines aim to induce an effective immune response against cancer, and the effectiveness of these vaccines is influenced by the choice of immunogen, vaccine type, and immunization strategy. Although treatment with cancer vaccines can improve tumor burden and survival, in most animal studies, it is challenging to achieve a complete response against tumor growth and recurrence, without the use of other therapies in combination.