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Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy

Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy

Source :

https://jitc.bmj.com/content/8/2/e001156?rss=1

Objectives Strategies to improve the responsiveness of programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade therapy remain an essential topic in cancer immunotherapy. In this study, we developed a new radiolabeled nanobody-based imaging probe 99mTc-MY1523 targeting PD-L1 for the enhanced therapeutic efficacy of PD-L1 blockade immunotherapy by the guidance of 99mTc-MY1523 SPECT/CT imaging.