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Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Source :

https://doi.org/10.1080/2162402X.2020.1824643

ABSTRACT Chimeric antigen receptor T (CAR-T) cell therapy has been applied successfully in treating hematologic malignancies; however, it shows very limited efficacy in treating solid tumors. Adenosine is one of the key immunosuppressive metabolites in tumor microenvironment (TME) of solid tumors.