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Immunotherapy with NK cells: recent developments in gene modification open up new avenues

Immunotherapy with NK cells: recent developments in gene modification open up new avenues

Source :

https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1777651

ABSTRACT Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects.