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The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment

The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment

Source :

https://doi.org/10.3389/fonc.2020.01221

Immunotherapy options for patients with cancer have emerged following decades of research on immune responses against tumors. Most treatments in this category harness T cells with specificity for tumor associated antigens, neoantigens, and cancer-testis antigens. GSK3β is a serine-threonine kinase with the highest number of substrates and multifaceted roles in cell function including immune cells.