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Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

Source :

https://doi.org/10.1080/2162402X.2020.1785608

ABSTRACT ABSTRACT Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize off-target and on-target/off-tumor reactions, improve safety, enable controllability, provide high flexibility, and increase tumor specificity, we established a novel humanized artificial receptor platform termed RevCARs.