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The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis

The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis

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https://doi.org/10.1080/2162402X.2020.1782575

ABSTRACT Myelofibrosis (MF) is characterized by chronic inflammation and hyper-activation of the JAK-STAT pathway. Infections are one of the main causes of morbidity/mortality. Therapy with Ruxolitinib (RUX), a JAK1/2 inhibitor, may further increase the infectious risk. Monocytes are critical players in inflammation/immunity through cytokine production and release of bioactive extracellular vesicles.