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BCMA-targeting Bispecific Antibody That Simultaneously... : Journal of Immunotherapy

BCMA-targeting Bispecific Antibody That Simultaneously... : Journal of Immunotherapy

Source :

https://journals.lww.com/immunotherapy-journal/Abstract/2020/07000/BCMA_targeting_Bispecific_Antibody_That.1.aspx

tive malignancies including MM. MICA activates natural killer (NK) cells and costimulates T cells by interaction with its immunoreceptor NK cell receptor G2D (NKG2D). Nonetheless, during full-blown MM, tumor cells promote efficient MICA shedding, which evokes NKG2D internalization and immune suppression.