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Triple Immunotherapy Overcomes Immune Evasion by Tumor in a Melanoma Mouse Model

Triple Immunotherapy Overcomes Immune Evasion by Tumor in a Melanoma Mouse Model

Source :

https://doi.org/10.3389/fonc.2020.00839

Background: Melanoma is a malignancy with increasing incidence that underlies most skin cancer-related deaths. Advanced melanoma patients still have poor prognosis despite recently developed immunotherapies. This study devises a triple immunotherapy to treat melanoma in a mouse model. The combination includes anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) antibodies, Monophosphoryl-lipid-A (MPLA), and an Indolamine-Dioxygenase-1 (IDO1) inhibitor.