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Measuring Intratumoral Heterogeneity of Immune Repertoires

Measuring Intratumoral Heterogeneity of Immune Repertoires

Source :

https://doi.org/10.3389/fonc.2020.00512

There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures-along with the associated heterogeneity of the tumor neoantigen landscape-but such analyses remain challenging to perform.