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ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer

ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer

Source :

https://doi.org/10.1080/2162402X.2020.1758003

ABSTRACT Despite some of the oncogenic driver mutations that have been associated with increased expression of programmed death-ligand 1 (PD-L1), the correlation between PD-L1 expression and ROS1 fusion in NSCLC cells, especially for those with Crizotinib resistance has not been fully addressed.