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CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models

CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models

Source :

https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1747688

ABSTRACT In our previous studies, using a B cell vaccine (scFv-Her2), the targeting of tumor-associated antigen Her2 (human epidermal growth factor receptor-2) to B cells via the anti-CD19 single chain variable fragment (scFv) was shown to augment tumor-specific immunity, which enhanced tumor control in the prophylactic and therapeutic setting.