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Prognostic value of CD73 expression in resected colorectal cancer liver metastasis

Prognostic value of CD73 expression in resected colorectal cancer liver metastasis

Source :

https://doi.org/10.1080/2162402X.2020.1746138

ABSTRACT ABSTRACT Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, the rate limiting enzyme that catalyzes the degradation of extracellular AMP into immunosuppressive adenosine, could be an immunological determinant of colorectal liver metastases (CRLMs).