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60-Year-Old Female with Swollen, Painful Right Knee

A 60-year old female presents to her primary care physician complaining of a swollen and painful right knee. She reports that she’s been suffering from her knee for approximately 3 weeks. Her history is unremarkable, except for the fact that the patient was diagnosed with metastatic non-small cell lung cancer within the past year. She reports that she is on a new treatment and feels better, other than her knee.

Her physician performs a physical exam and confirms an inflamed right knee. The PCP orders an erythrocyte sediment rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF).

In the meantime, her PCP suggests that she take non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for symptom relief.

What other laboratory tests and imagining tests would be appropriate for this patient?
What additional information should you seek from a patient who is in active cancer treatment?