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A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Source : https://www.nature.com/articles/s41587-019-0403-9

Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the safety of CAR-T-cell therapy, we computationally designed a chemically disruptable heterodimer (CDH) based on the binding of two human proteins.

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