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Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis

Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis

Source : https://doi.org/10.3389/fimmu.2020.00018

CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the escape of these cancer cells from macrophage-mediated phagocytosis.

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